Neurexin

Targeted splicing approach for alleviation of a neurexin 1 haploinsufficiency model

NRXN1 encoding the synaptic organizing protein neurexin 1 (Nrxn1) is among the strongest risk genes for autism spectrum disorders as …

Hong Lu, Kyle Roddick, Long Zuo, Peng Zhang, Olivia Lam, Klara Marsh, Rachel O.L. Wong, Richard E. Brown, Ann Marie Craig

Last updated on Jul 23, 2024

Interval Timing is altered in male Nrxn1+/- mice: Just as in Autism Spectrum Disorder

Autism spectrum disorder (ASD) is characterised by impaired social interaction and communication and increased repetitive and …

Kyle Roddick, Elias B. Habib, Richard E. Brown, Fuat Balcı

Last updated on Dec 31, 2023

Alternative Splicing and Heparan Sulfation Converge on Neurexin-1 to Control Glutamatergic Transmission and Autism-Related Behaviors

Neurexin synaptic organizing proteins are central to a genetic risk pathway in neuropsychiatric disorders. Neurexins also exemplify …

Hong Lu, Long Zuo, Kyle Roddick, Peng Zhang, Shinichiro Oku, Jessica Garden, Yuan Ge, Michael Bellefontaine, Mathias Delhaye, Richard E. Brown, Ann Marie Craig

Alternative Splicing and Heparan Sulfation Converge on Neurexin-1 to Control Glutamatergic Transmission and Autism-Related Behaviors