Autism Spectrum Disorder

Targeted splicing approach for alleviation of a neurexin 1 haploinsufficiency model

NRXN1 encoding the synaptic organizing protein neurexin 1 (Nrxn1) is among the strongest risk genes for autism spectrum disorders as …

Hong Lu, Kyle Roddick, Long Zuo, Peng Zhang, Olivia Lam, Klara Marsh, Rachel O.L. Wong, Richard E. Brown, Ann Marie Craig

Last updated on Jul 23, 2024

Interval Timing is altered in male Nrxn1+/- mice: Just as in Autism Spectrum Disorder

Autism spectrum disorder (ASD) is characterised by impaired social interaction and communication and increased repetitive and …

Kyle Roddick, Elias B. Habib, Richard E. Brown, Fuat Balcı

Last updated on Dec 31, 2023

Early Postnatal Development of the MDGA2+/- Mouse Model of Synaptic Dysfunction

Synaptic dysfunction underlies many neurodevelopmental disorders (NDDs). The membrane-associated mucin domain-containing …

Emre Fertan, Aimée A. Wong, Thalia S. Garvock-De Montbrun, Michaela K. Purdon, Kyle Roddick, Tohru Yamamoto, Richard E. Brown

Early Postnatal Development of the MDGA2+/- Mouse Model of Synaptic Dysfunction