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Targeted Splicing Approach for Alleviation of a Neurexin 1 Haploinsufficiency Model
NRXN1 encoding the synaptic organizing protein neurexin 1 (Nrxn1) is among the strongest risk genes for autism spectrum disorders as …
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Targeted Splicing Approach for Alleviation of a Neurexin 1 Haploinsufficiency Model
Motor deficits in the McGill-R-Thy1-APP transgenic rat model of Alzheimer’s Disease
The McGill-R-Thy1-APP rat is a transgenic model of Alzheimer’s Disease (AD) which expresses APP with two mutations found in cases of …
Last updated on May 23, 2025
Intranasal insulin treatment ameliorates spatial memory, muscular strength, and frailty deficits in 5xFAD mice
The 5xFAD mouse model shows age-related weight loss as well as cognitive and motor deficits. Metabolic dysregulation, especially …
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Intranasal insulin treatment ameliorates spatial memory, muscular strength, and frailty deficits in 5xFAD mice
Interval Timing is altered in male Nrxn1+/- mice: Just as in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is characterised by impaired social interaction and communication and increased repetitive and …
Last updated on Dec 31, 2023
Serial Reversal Learning in an Olfactory Discrimination Task in 3xTg-AD Mice
Male and female 3xTg-AD mice between 5 and 24 mo of age and their B6129F2/J wild-type controls were tested on a series of 18 olfactory …
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Serial Reversal Learning in an Olfactory Discrimination Task in 3xTg-AD Mice
Early Postnatal Development of the MDGA2+/- Mouse Model of Synaptic Dysfunction
Synaptic dysfunction underlies many neurodevelopmental disorders (NDDs). The membrane-associated mucin domain-containing …
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Early Postnatal Development of the MDGA2+/- Mouse Model of Synaptic Dysfunction
Alternative Splicing and Heparan Sulfation Converge on Neurexin-1 to Control Glutamatergic Transmission and Autism-Related Behaviors
Neurexin synaptic organizing proteins are central to a genetic risk pathway in neuropsychiatric disorders. Neurexins also exemplify …
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Alternative Splicing and Heparan Sulfation Converge on Neurexin-1 to Control Glutamatergic Transmission and Autism-Related Behaviors
A Signal Detection Analysis of Olfactory Learning in 12-Month-Old 5xFAD Mice
Although Alzheimer’s disease is most often studied in terms of memory impairments, olfactory dysfunction begins in the early stages. We …
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A Signal Detection Analysis of Olfactory Learning in 12-Month-Old 5xFAD Mice
Neural Correlates of the Production Effect: An fMRI Study
Recognition memory is improved for items produced at study (e.g., by reading them aloud) relative to a non-produced control condition …
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Neural Correlates of the Production Effect: An fMRI Study
Age Related Weight Loss in Female 5xFAD Mice from 3 to 12 Months of Age
In addition to cognitive decline, patients with Alzheimer’s disease (AD) exhibit sensory, motor, and neuropsychiatric deficits. …
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Age Related Weight Loss in Female 5xFAD Mice from 3 to 12 Months of Age